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doi: 10.1016/j.bbi.2019.05.030 108 OhSSoRShidaTMatsuoTKimBAkiyamaKet al

Primary MCA is when categorized as an abnormal production of mast cells, whereas secondary is normal mast cells that are activated by micro-environmental triggers

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This could explain why some people experience significant relief from allergy-like symptoms when supplementing with riboflavin or consuming B-vitamin-rich foods